It is intriguing how tightly-orchestrated neuronal networks fulfill, what we are appreciating as our mind and what ultimately helps us to define our personality. It is one of our most valuable skills that defines mankind, the ability to create new thoughts and learn from experience. From this it becomes clear that diseases of the central nervous system can present a tremendous burden for individuals and their families. Our group wants to understand the mechanisms of central nervous system (CNS) diseases and their effect on natural processing of information and cognitive processes.

We make use of cutting-edge in vivo microscopy techniques, combined with neuronal manipulation tools and behavioral readouts in transgenic mice, to investigate diseases of the central nervous system from the subcellular to the functional level.